It is crucial to use a colon-targeted medication delivery system to treat diseases that start in the colon, such as inflammatory bowel disease, colon cancer, amoebiasis, and irritable bowel syndrome. Through colon targeted drug delivery system, we can give localised treatment to the patient which reduces the chance of toxicity and improves its therapeutic efficacy. The bioavailability of medications for the colon has greatly increased because to recent improvements in oral formulations. But because it is intimately linked to GI Inflammation, it is crucial to make some changes to the Gastrointestinal (GI) physiology to increase the therapeutic effect even more. Due to their structural makeup and smaller size, nanoparticles are often used in the administration of drugs that are specifically targeted for the colon. It is designed in such a way that it promotes aggregation time of drugs at the site of action, supporting localized therapy. This review article mainly focuses on oral nanoparticulate formulations that are targeted for treating Colon related diseases.