Anabolic Androgenic Steroids Induced Iatrogenic Cushing Syndrome in a Patient with Relapse of Antitubercular Drugs Induced Hepatitis

1Department of Pharmacy Practice, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, INDIA

Corresponding author.

Correspondence: Dr. Bandaru Yeswanth Raja Department of Pharmacy Practice, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi-590010, Karnataka, INDIA. Email: yashmohan2979@gmail.com
Received February 08, 2023; Revised February 27, 2023; Accepted April 06, 2023.
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Citation

1.Raja BY, Ganachari MS. Anabolic Androgenic Steroids Induced Iatrogenic Cushing Syndrome in a Patient with Relapse of Antitubercular Drugs Induced Hepatitis. Journal of Young Pharmacists [Internet]. 2023 Aug 25;15(3):581–4. Available from: http://dx.doi.org/10.5530/jyp.2023.15.81
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Published in: Journal of Young Pharmacists, 2023; 15(3): 581-584.Published online: 22 August 2023DOI: 10.5530/jyp.2023.15.81

ABSTRACT

Anabolic androgenic steroids are a type of synthetic testosterone which are most likely used by athletes, body builders and physicians to increase male sex hormones in those who have not yet reached puberty. We present the case of 32-years-old male patient who was admitted in respiratory ward with complaints of breathlessness and weakness. Patient had history of left hydropneumothorax secondary due to pulmonary tuberculosis, iatrogenic cushing syndrome and was misusing anabolic androgenic steroids for muscle gain for a long time. The laboratory investigations were noted that elevation of liver function tests, abnormal haematological tests, ultrasonography was revealed to be hepatomegaly with grade II fatty liver. The patient was treated with the Dexamethasone, combination of Piperacillin and Tazobactam, combination of Metadoxine, Silymarin and l-Ornithinel-Aspartate (LOLA), Clonazepam, Ketoconazole and his health condition improved enough for him to be discharged. In conclusion we recommend the health care professionals to review the safety profile, examine laboratory results and counsel patients to prevent further abusage of anabolic androgenic steroids.

Keywords: Anabolic androgenic steroids, Iatrogenic cushing syndrome, Hepatitis, tuberculosis, Adverse events