Short Term Prognosis in Patients with Diabetes Mellitus after Coronary Revascularization

1Department of Pharmacy Practice. Annamalai University, Chidambaram, Tamil Nadu, INDIA

2Department of Pharmacology, Prime College of Pharmacy, Palakkad, Kerala, INDIA

Corresponding author.

Correspondence: Mrs. Leena Varghese Annamalai University Chidambaram, Prime College of Pharmacy, Palakkad, Kerala, INDIA. Email: leena28492@gmail.com
Received December 12, 2023; Revised January 05, 2024; Accepted January 12, 2024.
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Citation

1.Varghese L, Kannaiyan Dhanapal C, Sengottuvel T. Short Term Prognosis in Patients with Diabetes Mellitus after Coronary Revascularization. Journal of Young Pharmacists [Internet]. 2024 Feb 15;16(1):81–7. Available from: http://dx.doi.org/10.5530/jyp.2024.16.11
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Published in: Journal of Young Pharmacists, 2024; 16(1): 81-87. Published online: 07 July 2025DOI: 10.5530/jyp.2024.16.11

ABSTRACT

Background: Cardiovascular disease often advances rapidly in people with diabetes mellitus, resulting in unfavorable clinical outcomes and complications after revascularization procedures. The purpose of our study was to determine how baseline parameters and Diabetes Mellitus (DM) affected clinical outcomes in the immediate aftermath of revascularization. Materials and Methods: For this investigation, 189 patients who underwent CABG (Coronary Artery Bypass Graft) and PCI (Percutaneous Coronary Intervention) operations for revascularization during a five-month period in a South Indian tertiary care hospital were the subject of a hospital-based prospective observational analysis. During the first 30 days following revascularization, patients were assessed for clinical outcomes and baseline characteristics in the diabetic and non-diabetic groups. To ascertain the relevance of the findings, statistical analyses were carried out. Results: The study reveals that there is no statistically significant difference in the type of surgery, number of grafts or stents, urgency of the surgery, angiographic finding, length of ventilation, volume of the chest drain, stay in the cardiothoracic unit, and length of hospitalization between the diabetes and non-diabetic cohorts. Arrhythmia, stroke after revascularization, re-exploration within discharge mortality, pulmonary embolism, hemorrhage, perioperative mortality, and postoperative mortality within 30 days were evaluated as follow-up events in both the groups and determined to be insignificant. Conclusion: Even though prevalence of Cardiovascular Disease (CVD) is higher in diabetics, when comparing the diabetic and non-diabetic cohorts, it is not regarded as a risk factor for any negative outcomes following revascularization immediately within a period of thirty days following the angioplasty.

Keywords: Coronary artery bypass graft, Coronary Revascularization, Diabetes mellitus, Clinical outcome, Coronary artery disease, Percutaneous coronary intervention