Association of Serum Inhibin B and Primary Male Reproductive Hormone with Semen Quality in Normal and Infertile Men

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Association of Serum Inhibin B and Primary Male Reproductive Hormone with Semen Quality in Normal and Infertile Men
J Young Pharm. Vol 15/Issue 3/2023 
Ragesh Gurumoorthi1, Radha Vembu2, Cheekala Uma Maheshwara Reddy3 and Anjalakshi Chandrasekar4
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1Department of Reproductive Medicine, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai, Tamil Nadu, INDIA

2Department of Pharmacy Practice, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai, Tamil Nadu, INDIA

3Department of Pharmacology, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai, Tamil Nadu, INDIA

4Department of Obstetrics and Gynaecology, AC Hospital, Ayanavaram, Chennai, Tamil Nadu, INDIA

Corresponding author.

Correspondence: Dr. Radha Vembu Department of Reproductive Medicine, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai, Tamil Nadu, INDIA. Email: ganesh_radha@yahoo.in
Received April 03, 2023; Revised May 18, 2023; Accepted June 26, 2023.
Copyright 2023 Authors
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Citation

1.Gurumoorthi R, Vembu R, Reddy CUM, Chandrasekar A. Association of Serum Inhibin B and Primary Male Reproductive Hormone with Semen Quality in Normal and Infertile Men. Journal of Young Pharmacists [Internet]. 2023 Aug 25;15(3):506–12. Available from: http://dx.doi.org/10.5530/jyp.2023.15.67
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Published in: Journal of Young Pharmacists, 2023; 15(3): 506-512. Published online: 22 August 2023DOI: 10.5530/jyp.2023.15.67

ABSTRACT

Background

Inhibin B, which is produced in the testis from Sertoli cells, functions in the negative feedback process for the release of Follicle Stimulating Hormone (FSH). These hormones appear to be crucial indicators for the health of somniferous tubules, where spermatozoa were formed from germ cells. The present study designed to assess the role of inhibin B, FSH, testosterone and Luteinizing Hormone (LH) on semen quality (sperm morphology, concentration, and total motility of sperms) in normal and infertile men.

Materials and Methods

This study was conducted in the department of reproductive medicine with a cross-sectional study design. In normal and infertile groups, the participants were enrolled as 1:2 ratios. Following 4-5 days of sexual abstinence, men’s fresh semen samples were obtained, and the samples were then tested for semen quality using the World Health Organization (WHO) 2010 handbook. Using the Chemiluminescent Immune Assay (CLIA) and Enzyme-Linked Immunosorbent Assay (ELIZA) approach, blood samples were taken, serum was separated for inhibin B, FSH, testosterone and luteinizing hormone analysis, and the correlation was evaluated using the Spearman’s correlation test.

Results

It was found that inhibin B level was higher in normal group (p=0.0005) whereas FSH level was higher in infertile group (p=0.001). It was found that, a significant and hostile correlation among inhibin B and FSH in the normal and infertile group. In infertile group inhibin B shows the positive correlation with total sperm concentration in semen (r=0.175* p=0.023) and adversative correlation with non-progressive motility (r=0.184* p=0.050). FSH noted hostile correlation with tail defects (r=-0.235* p=0.012). In normal group, it was noted that optimistic correlation between inhibin B and progressive motility (r=0.280* p=0.035) and there are no negative correlations were noted. Testosterone had negative correlation with FSH and LH. Testosterone showed positive correlation with sperm concentration. The sperm concentration and total motility shown optimistic correlation with LH.

Conclusion

Consistent with other study, this study finding infers the stout correlation between the inhibin B and FSH with semen quality in infertile male in South India.

Keywords: Spermatozoa, Total sperm concentration, Motility, Vitality, Hormones